Lim Group

Department of Biochemistry, University of Otago

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Welcome to the website of Dr Chun Shen Lim’s computational genomics group. We aim to delineate molecular factors that control gene expression using high-throughput techniques and computational pipelines we develop. Our goal is to address health issues and infectious diseases, e.g., hepatitis B virus infection.

news

Dec 01, 2023 Congratulations Gabrielle on her well-deserved PhD scholarship! :sparkles: :smile:
Sep 25, 2023 Gabrielle won the travel award from the Molecular Biosystems Fellows Program and attended the conference in Puerto Varas, Chile. Well done! :beers:
May 25, 2023 We have successfully secured a HRC Explorer Grant :partying_face:
May 01, 2023 Welcome Gabrielle and Anh! Our new PhD students :confetti_ball:
Dec 18, 2021 Congratulations to Bikash on receiving his doctoral degree and starting an exciting career at EBI :tada:

selected publications

  1. The exon–intron gene structure upstream of the initiation codon predicts translation efficiency
    Chun Shen Lim, Samuel J T Wardell , Torsten Kleffmann , and 1 more author
    Nucleic Acids Research, 2018
    32 Google Scholar citations
  2. Solubility-Weighted Index: fast and accurate prediction of protein solubility
    Bikash K Bhandari , Paul P Gardner , and Chun Shen Lim
    Bioinformatics, 2020
    42 Google Scholar citations
  3. Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes
    Chun Shen Lim, Vitina Sozzi , Margaret Littlejohn , and 5 more authors
    Microbial Genomics, 2021
    22 Google Scholar citations
  4. Analysis of 11,430 recombinant protein production experiments reveals that protein yield is tunable by synonymous codon changes of translation initiation sites
    Bikash K Bhandari , Chun Shen Lim, Daniela M Remus , and 3 more authors
    PLOS Computational Biology, 2021
    18 Google Scholar citations
  5. TISIGNER.com: web services for improving recombinant protein production
    Bikash K Bhandari , Chun Shen Lim, and Paul P Gardner
    Nucleic Acids Research, 2021
    22 Google Scholar citations
  6. Analysis of fungal genomes reveals commonalities of intron gain or loss and functions in intron-poor species
    Chun Shen Lim, Brooke N Weinstein , Scott W Roy , and 1 more author
    Molecular Biology and Evolution, 2021
    24 Google Scholar citations