Lim Group

Welcome to the website of Dr Chun Shen Lim’s computational genomics group. We aim to delineate molecular factors that control gene expression using high-throughput techniques and computational pipelines we develop. Our goal is to address health issues and infectious diseases, e.g., hepatitis B virus infection.

news

Dec 01, 2023	Congratulations Gabrielle on her well-deserved PhD scholarship!
Sep 25, 2023	Gabrielle won the travel award from the Molecular Biosystems Fellows Program and attended the conference in Puerto Varas, Chile. Well done!
May 25, 2023	We have successfully secured a HRC Explorer Grant
May 01, 2023	Welcome Gabrielle and Anh! Our new PhD students
Dec 18, 2021	Congratulations to Bikash on receiving his doctoral degree and starting an exciting career at EBI

selected publications

The exon–intron gene structure upstream of the initiation codon predicts translation efficiency

Chun Shen Lim, Samuel J T Wardell , Torsten Kleffmann , and 1 more author

Nucleic Acids Research, 2018
Solubility-Weighted Index: fast and accurate prediction of protein solubility

Bikash K Bhandari , Paul P Gardner , and Chun Shen Lim

Bioinformatics, 2020
Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes

Chun Shen Lim, Vitina Sozzi , Margaret Littlejohn , and 5 more authors

Microbial Genomics, 2021
Analysis of 11,430 recombinant protein production experiments reveals that protein yield is tunable by synonymous codon changes of translation initiation sites

Bikash K Bhandari , Chun Shen Lim, Daniela M Remus , and 3 more authors

PLOS Computational Biology, 2021
TISIGNER.com: web services for improving recombinant protein production

Bikash K Bhandari , Chun Shen Lim, and Paul P Gardner

Nucleic Acids Research, 2021
Analysis of fungal genomes reveals commonalities of intron gain or loss and functions in intron-poor species

Chun Shen Lim, Brooke N Weinstein , Scott W Roy , and 1 more author

Molecular Biology and Evolution, 2021